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Tender point sensitivity may also begin to improve during this period, with some patients noting they can tolerate light touch or pressure that previously caused significant discomfort

There is a continuum in patient management, with paediatric to adult hepatologists collaborating with geneticists

The collagen stimulation isn't just quantitative

Apurinic/Apyrimidinic Endonuclease Apurinic/apyrimidinic endonuclease (APE1) is also known as redox effector factor 1 (RF1), human AP endonuclease 1 (HAP1), or apurinic/apyrimidinic endodeoxyribonuclease 1 (APEX1